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Andrew Resnick

Department of Physics                                                                             Phone: (216)-687-XXXX
Cleveland State University
2121 Euclid Avenue
Cleveland Ohio  44115                                                                      email: a.resnick@csuohio.edu

Education:

July 1997:        Ph.D. in Physics University of Alabama in Huntsville, Huntsville, AL

  • Dissertation Title: Statics and Dynamics of Vibrating Liquid Bridges, (J. Iwan D. Alexander, advisor)

June 1991:       B.S. in Physics, Rensselaer Polytechnic Institute, Troy, NY

Honors and Awards:

2003-current    NIH K25 Mentored Quantitative Research Award
2005                Research ShowCASE outstanding Postdoctoral Poster award
2000                Member, Outstanding Technical Team for Mine Detection Data Collection
1993-1997       NASA Graduate Student Research Program Grant

Research Experience:

2009-Present   Assistant Professor, Department of Physics, Cleveland State University
2009-Present   Assistant Professor (secondary appointment), Department of Biology, Geology and Environmental Sciences, Cleveland State University
2009-Present   Adjunct Staff, Department of Cell Biology, Cleveland Clinic Foundation
2009-Present   Adjunct Assistant Professor, Department of Physiology and Biophysics, Case Western Reserve University
2005-2009       Instructor, Department of Physiology and Biophysics
2004-2005       Post-doctoral Fellow, Department of Physiology and Biophysics

  • The role of sensory cilia in cellular mechanosensation. Systems under investigation include renal and airway epithelial tissue. Primary experimental probes are laser tweezers, microscopy, and two-sided perfusion chambers.

2003-2004       Research Staff, National Center for Microgravity Research at NASA Glenn Research Center
1999- 2003      Senior Scientist, Northrop Grumman at NASA Glenn Research Center

  • Senior member of the Light Microscopy Module (LMM) development team, responsible for the development of a fully automated microscope.
  • Development of novel spaceflight instrumentation (laser tweezers), spaceflight modifications to new microscopy technologies (confocal microscopy, spectrophotometer), and static and dynamic light scattering.
  • Direct experience with a wide range of equipment including solid-state lasers, fiber optic systems, optical test and measurement equipment, acousto-optic and electro-optic modulators, digital cameras and interfaces, image processing and optical system design.
  • Participated in several KC-135 reduced gravity flights, experienced over 400 zero-g parabolas.

1997 – 1999     Research Scientist, Nichols Research Corporation

  • Responsible for the development of an accurate physical model for passive and active sensor simulations.  Added polarization effects, millimeter wave imaging, rough surface scattering and improved thermal flow models.
  • Developed and used a dual rotating retarder Mueller matrix spectropolarimeter with the goal of obtaining highly accurate and precise surface scattering measurements.

1992- 1997      Experimental investigation into dynamic behavior of contact line and contact angle of liquid bridges (Ph.D. dissertation).

  • Fundamental research of a basic physical phenomena (liquid bridges) common to many technological processes, e.g. floating-zone crystal growth, fluid flow in porous materials, and adhesion
  • Constructed a neutral buoyancy (Plateau) tank, computer controlled motion equipment, Schlieren, Fourier, and imaging optical systems
  • Developed innovative and accurate measurements of contact angle and interfacial energy in reduced gravity conditions

Teaching Experience:

2009-Present      Assistant Professor, Department of Physics, Cleveland State University

  • PH 221 (College Physics I),  Fall 2009, 2010
  • PH 222 (College Physics II), Spring 2010, 2011

2003-2009       Instructor, Department of Physiology and Biophysics, Case Western Reserve University

  • Anat/Phol 517, “Optical Imaging and Microscopy for Biologists” May 19-23, 2003 (Anna-Liisa Nieminen, course director)
  • Anat/Phol 517, “Optical Imaging and Microscopy for Biologists” May 23-28, 2004 (Anna-Liisa Nieminen, course director)
  • PHOL 476, “Cellular Biophysics”, Spring 2005 (Ulrich Hopfer, course director)
  • PHOL 476, “Cellular Biophysics”, Spring 2006 (Ulrich Hopfer, course director)
  • PHOL 476, “Cellular Biophysics”, Spring 2007 (Ulrich Hopfer, course director)
  • MBIO 525, “Advances in Biological Imaging”, Fall 2006 (David McDonald, course director)
  • GENE 537, “Light and Video Microscopy”, Fall 2007 (Patty Conrad, course director)
  • Block 2 small group “Cell signaling” 8/25/08 (George Dubyak, course coordinator)
  • Block 2 small group “Cell signaling” 8/27/07 (George Dubyak, course coordinator)
  • Trained over 20 microscopy users as manager of the Cystic Fibrosis Center Core Imaging Laboratory

2000-2001       Lecturer, Department of Physics, Case Western Reserve University.

  • PHYS 115, “Physics I”, Summer 2000
  • PHYS 115, “Physics I” and PHYS 121 “Mechanics”, Fall 2000

1997-1999              Research Scientist, Nichols Research Corporation

  • “Infrared phenomenology” (in-house training)
  • “Polarization and Polarimetry” (in-house training)

Research Support:

Grant Number: 1 K25 DK071027-01 (NIH/NIDDK)
Project Title:  Flow Effects on Primary Cilium Deflection
Project dates: July 1, 2005- June 30, 2010
Project Summary:
The research plan will investigate the possible role of the primary cilium in renal epethilial cells as a mechanical sensor of the cell’s external environment, and the metabolic pathways that are regulated by that sensing mechanism.

Grant Number: Cystic Fibrosis Foundation R447-CR02
Project Title:    Role of Primary Cilium in Airway Surface Liquid Regulation
Project dates:  July 1, 2006-June 30, 2008
Project Summary:
It is hypothesized that the motile cilia act as a mechanical sensor, and that dysfunction of the cilia causes uncontrolled volume transport through the pulmonary epithelium. This proposal focuses on possible mechanical pathways, by examining how the beating cilia could sense the state of the fluid layer by, for example, sensing the resistance to movement (viscosity).

NIH NCRR Shared Instrumentation Grant Program
Project Title:    Upright Light Microscope Workstation
Project dates:  4/1/2006-3/31/2007
Project Summary:
This grant consists of an award to purchase an automated upright microscope fitted for imaging live epithelial cell monolayers grown on suspended filters.

Grant Number: PENDING: NSF
Project Title:  CAREER: In Vitro Tests of Cellular Mechanosensation Mediated by the Primary Cilium
Project dates: July 1, 2011- June 30, 2016
Project Summary:
In this proposed CAREER project, I, serving as the project PI, will 1) measure the sensitivity of the primary cilium to applied mechanical forces in the context of renal epithelial mechanosensation, and 2) will ensure the results obtained are physiologically relevant by relating in vitro experimental conditions to the available in vivo data.

Grant Number: PENDING: NIH
Project Title: Fluid flow is an environmental modifier of ADPKD
Project dates: July 1, 2011- June 30, 2014
Project Summary:
The hypothesis to be addressed by this proposal is: fluid flow is an environmental modifier of ADPKD disease progression. The experimental approach used will quantitatively control the mechanical stimulation applied to differentiated murine renal epithelial tissue while measuring several physiologically-relevant cellular readouts implicated in ADPKD.

Peer-reviewed Papers:

Resnick A, “Use of optical tweezers to probe epithelial mechanosensation”, J. Biomedical Optics 2010 January/February  15 (1), 015005 1-8.

Yu Cheng, Anna C. Samia, Jun Li, Ping Zhang, Malcolm E. Kenney, Andy Resnick, Clemens Burda,, Quantification the Release of a Gold Nanoparticle-Caged PDT Drug Pc 4 into Human Cancer Cells”, Langmuir, 2009 Aug 31, Epub ahead of print (feature article)

Resnick A, Hopfer U. “Mechanical stimulation of primary cilia”, Frontiers in Bioscience 2008 Jan 1;13:1665-80.

Resnick A, Hopfer U. “Force-response considerations in ciliary mechanosensation.”, Biophys J. Aug 15;93(4): 2007, 1380-90. Epub 2007 May 25.

Resnick A, “Use of laser tweezers for colloid science”, J. Colloid and Interface Science 262, 2003, 55-59.

Resnick A, Differential interference contrast microscopy as a polarimetric instrument”, Applied Optics 41, 2002, 38-45

Resnick A, “Design and Construction of a space-borne optical tweezer apparatus”, Review of Scientific Instruments 72, 2001, 4059-4065.

Resnick A, Persons C., and Lindquist G., “Polarized Emissivity and Kirchhoff’s Law”, Applied Optics 38, 1999, 1384-1387.

Watson J., Wellfare M., Foster J., Owens M., Vechinski D., Richards M., and Resnick A, “Irma Multisensor Predictive Signature Model”, Proc. SPIE Vol. 3375, p. 78-92, Targets and Backgrounds: Characterization and Representation IV, Wendell R. Watkins; Dieter Clement; Eds. (1998).

Resnick A and Alexander J.I.D., “A Coherent Fourier Optical Imaging System for Liquid Bridge Research” (Proceedings of the SPIE Aerosense 1997 meeting, vol 3073)

Resnick A and Alexander J.I.D., “A Plateau tank apparatus for liquid bridge research” Review of Scientific Instruments 68 (3), 1997, 1495-1500.

Slobozhanin L., Alexander J.I.D., and Resnick A, “Bifurcation of the equilibrium states of a weightless liquid bridge”, Phys. Fluids 9 (7), 1997, 1893-1905.

Technical Reports:

Resnick, A., “Light Microscopy Module Baseline Performance Document”, document # LMM-DOC-0021, prepared for NASA Glenn Research Center, (2001)

Presentations:


2010 Regional American Physics Society, October 7-8, Marietta, OH
2010 Ohio Physiological Society, October 14-15, Cleveland, OH (poster)
2009 Gordon Conference on Cilia, Mucus & Mucociliary Interactions, February 4 – 9, Il Ciocco, Italy (poster)
2008 Future Directions Workshop, Advanced Photon Source, Argonne National Laboratory, October 20-21, IL (Invited speaker)
2008 FASEB meeting, April 5-9, San Diego, CA (invited speaker)
2008 FASEB meeting, April 5-9, San Diego, CA (poster)
2007 Research ShowCase 4/11/07, Cleveland OH (poster)
2007 CaseMed new Faculty 4/18/07, Cleveland OH (poster)
2007 Gordon Conference on Cilia, Mucus & Mucociliary Interactions, February 4 – 9, Ventura Beach Marriott, Ventura Beach, CA (poster)
2007 Biophysical society meeting, Baltimore, MD (poster)
2006 FASEB meeting, April 1-5, 2006 San Francisco, CA. (poster)
2005 Gordon Research Conference on Cilia, Mucus, and Mucociliary Interactions, Feb 27- Mar 4, Buellton, CA, 2005. (poster)
A. Resnick, “The Primary Cilium as a Flow Sensor”, (poster), presented at Research ShowCASE,  April 6 and 7, Cleveland, OH, 2005.
P.M. Chaikin, W.B. Russel, M.T. Sullivan, A.D. Hollingsworth, A. van Blaaderen, W.V. Meyer and M.P. Doherty, A.H. Resnick, “Physics of Hard Spheres Experiment-2 (PHSE‑2)”, AIAA-2001-4958, (Presented at 2001 ISS Utilization Conference)
A. Resnick, “Design and Construction of a space-borne optical tweezer apparatus” (Presented at the 2001 Conference on Lasers and Electro-Optics)
A. Resnick, “The Light Microscopy Module: An Autonomous, Multifunction, Space Borne Microscope” (Presented at the 2001 Conference on Lasers and Electro-Optics)
C. T. Lant and A. Resnick, “Multi-function Light Microscopy Module for the International Space Station” (Presented at the 2000 Space Technology Applications International Forum)
A. Resnick, B. Williams, and D. Goldstein, “Modeling Polarization in the Irma Synthetic Imaging Code” (Presented at the 1998 OSA annual meeting)
A. Resnick, J.I.D. Alexander and L. Slobozhanin, “Influence of support geometry and gravity on the stability of liquid bridges” (Presented at 1996 APS Fluids meeting)
A. Resnick, “Dynamics of liquid bridges: Importance of support geometry and contact line and angle dynamics” (Presented at 1995 NASA GSRP meeting)

Professional Societies:


Optical Society of America (1997-current)
American Physical Society (1992-current)
American Physiological Society (2003- current)
Sigma Xi (2006-current)

Reviewer:

  • Optics Letters, 2004-current
  • Applied Optics, 2005-current
  • Archives of Biochemistry and Biophysics, 2005-current
  • Optical Engineering, 2006-current

Academic Service:

Faculty Senate (2010-2012)
College of Science and Health Professions Dean Search Committee (2010)

Posted August 27, 2010 by resnicklab

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